Zhuo G Chen Selected Research

RSK inhibitor FMK

11/2013

The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis.

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Zhuo G Chen Research Topics

Disease

32	Neoplasms (Cancer) 11/2021 - 06/2012
16	Squamous Cell Carcinoma of Head and Neck 11/2021 - 06/2012
11	Head and Neck Neoplasms (Head and Neck Cancer) 01/2021 - 09/2011
6	Neoplasm Metastasis (Metastasis) 01/2020 - 06/2012
5	Lung Neoplasms (Lung Cancer) 08/2017 - 10/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2017 - 10/2013
1	Human Influenza (Influenza) 01/2021
1	Mouth Neoplasms (Oral Cancer) 04/2020
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2020
1	Necrosis 11/2017
1	Lymphatic Metastasis 09/2012

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2013
4	Biomarkers (Surrogate Marker)IBA 11/2020 - 11/2013
3	Cetuximab (Erbitux)FDA Link 11/2021 - 07/2014
3	Small Interfering RNA (siRNA)IBA 01/2020 - 09/2012
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 12/2017
3	Messenger RNA (mRNA)IBA 01/2016 - 10/2013
3	ErbB Receptors (EGF Receptor)IBA 10/2015 - 01/2013
2	Biological ProductsIBA 01/2021 - 03/2017
2	AntigensIBA 01/2021 - 01/2021
2	IntegrinsIBA 01/2020 - 09/2012
2	Cisplatin (Platino)FDA LinkGeneric 10/2019 - 01/2016
2	Cadherins (E-Cadherin)IBA 01/2019 - 09/2011
2	seribantumabIBA 02/2017 - 07/2014
2	Everolimus FDA Link 01/2017 - 06/2015
2	CurcuminIBA 01/2014 - 06/2012
2	Niclosamide FDA Link 10/2013 - 01/2013
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 10/2013 - 01/2013
1	Farnesyltranstransferase (Farnesyltransferase)IBA 11/2021
1	Annexin A5IBA 11/2021
1	tipifarnib (R115777)IBA 11/2021
1	cabozantinibIBA 01/2021
1	ARQ 197IBA 01/2021
1	CrizotinibIBA 01/2021
1	AfatinibIBA 01/2021
1	AntibodiesIBA 01/2021
1	EpitopesIBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	NeuregulinsIBA 01/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021
1	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2021
1	Immune Checkpoint InhibitorsIBA 04/2020
1	VaccinesIBA 04/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	ras ProteinsIBA 01/2020
1	lestaurtinibIBA 10/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 10/2019
1	Interleukin-6 (Interleukin 6)IBA 09/2019
1	Mechanistic Target of Rapamycin Complex 2IBA 01/2019
1	MTOR InhibitorsIBA 01/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2019
1	DONSIBA 01/2018
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2018
1	GoldIBA 11/2017
1	Phenformin (Fenformin)IBA 08/2017
1	Therapeutic UsesIBA 08/2017
1	AZD 6244IBA 08/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2017
1	2,9-di-sec-butyl-1,10-phenanthrolineIBA 01/2016
1	LigandsIBA 01/2016
1	Caspase 8 (Caspase-8)IBA 12/2015
1	TNF Receptor-Associated Factor 2 (TRAF2)IBA 12/2015
1	Apoptosis Regulatory ProteinsIBA 12/2015
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 12/2015
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 12/2015
1	PhytochemicalsIBA 12/2015
1	Neuregulin-1 (Neuregulin 1)IBA 10/2015
1	human ERBB2 proteinIBA 10/2015
1	BDA-366IBA 06/2015
1	Monoclonal AntibodiesIBA 07/2014
1	TubulinIBA 03/2014
1	UBS109IBA 01/2014
1	LuteolinIBA 01/2014
1	PolymersIBA 01/2014
1	90-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 90 kDa)IBA 11/2013
1	Microfilament Proteins (Actin Binding Proteins)IBA 11/2013
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 11/2013
1	RSK inhibitor FMKIBA 11/2013
1	Carrier Proteins (Binding Protein)IBA 11/2013
1	Phosphotransferases (Kinase)IBA 10/2013
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 07/2013
1	MAP Kinase Kinase Kinase 5IBA 07/2013
1	Cyclic AMP (AMP, Cyclic)IBA 07/2013
1	matrigelIBA 09/2012
1	3,5- bis(2- pyridinylmethylidene)- 4- piperidoneIBA 06/2012
1	Transcription Factors (Transcription Factor)IBA 06/2012

Therapy/Procedure

13	Therapeutics 01/2021 - 01/2013
2	Chemoprevention 11/2020 - 01/2014
1	Immunotherapy 04/2020
1	Photothermal Therapy 11/2017
1	Induced Hyperthermia (Thermotherapy) 01/2012